Structural Modifications of Proteins During Aging
نویسندگان
چکیده
منابع مشابه
Structural modifications of proteins during aging.
ging is a fundamental phenomenon that affects somatic A cells whose manifestations, however, may differ from one cell type to another. While most of us possess an intuitive understanding of what aging is, and can tell a young person from an old one, a precise definition of aging and its relationship to development has been surprisingly difficult to develop. The phenomenon of senescence can be d...
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Slowing down of bulk protein synthesis is one of the most commonly observed biochemical changes during aging. The implications and consequences of slower rates of protein synthesis are manifold, including a decrease in the availability of enzymes for the maintenance, repair, and normal metabolic functioning of the cell, an inefficient removal of inactive, abnormal, and damaged macromolecules in...
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Ribosomal proteins of the model gram-positive bacterium B. subtilis 168 were extensively characterized in a proteomic study. Mass spectra of the 52 proteins expected to be constitutive components of the 70S ribosome were recorded. Peptide MS/MS analysis with an average sequence coverage of 85% supported the identification of these proteins and facilitated the unambiguous assignment of post-tran...
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SIGNIFICANCE The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are connected to functional consequences. The modification of tyrosine (Tyr) residu...
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ژورنال
عنوان ژورنال: Journal of the American Geriatrics Society
سال: 1997
ISSN: 0002-8614
DOI: 10.1111/j.1532-5415.1997.tb01518.x